Radial Force and Lattice Spacing with Multi-Spring Crossbridge Models
نویسندگان
چکیده
منابع مشابه
Axial and Radial Forces of Cross-Bridges Depend on Lattice Spacing
Nearly all mechanochemical models of the cross-bridge treat myosin as a simple linear spring arranged parallel to the contractile filaments. These single-spring models cannot account for the radial force that muscle generates (orthogonal to the long axis of the myofilaments) or the effects of changes in filament lattice spacing. We describe a more complex myosin cross-bridge model that uses mul...
متن کاملIn situ measurements of crossbridge dynamics and lattice spacing in rat hearts by x-ray diffraction: sensitivity to regional ischemia.
BACKGROUND Synchrotron radiation has been used to analyze crossbridge dynamics in isolated papillary muscle and excised perfused hearts with the use of x-ray diffraction techniques. We showed that these techniques can detect regional changes in rat left ventricle contractility and myosin lattice spacing in in situ ejecting hearts in real time. Furthermore, we examined the sensitivity of these i...
متن کاملRandom Matrix Models for Dirac Operators at finite Lattice Spacing
We study discretization effects of the Wilson and staggered Dirac operator with Nc > 2 using chiral random matrix theory (chRMT). We obtain analytical results for the joint probability density of Wilson-chRMT in terms of a determinantal expression over complex pairs of eigenvalues, and real eigenvalues corresponding to eigenvectors of positive or negative chirality as well as for the eigenvalue...
متن کاملForce suppression and the crossbridge cycle in swine carotid artery.
Cyclic nucleotides can relax arterial smooth muscle without reductions in crossbridge phosphorylation, a process termed force suppression. There are two potential mechanisms for force suppression: 1) phosphorylated crossbridges binding to thin filaments could be inhibited or 2) the attachment of thin filaments to anchoring structures could be disrupted. These mechanisms were evaluated by compar...
متن کاملat non - zero lattice spacing ∗
A review of chiral perturbation theory for lattice QCD at non-zero lattice spacing is given.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.3007